Pancreatic cancer is one of the most aggressive malignant tumors of the digestive system. Lymph node metastasis (LNM), as the main way of invasion and metastasis, can occur in the early stage of pancreatic cancer and be considered the most important factor affecting the clinical treatment and prognosis of patients with pancreatic cancer. Previous studies have found that the incidence of lymphatic invasion of cancer cells is 3–5 times higher than that of vascular invasion.1 Although LNM of pancreatic cancer has obvious clinical importance, the specific molecular mechanism is still unclear.