MicroRNAs (miRNAs) have been found to play an important role in human tumorigenesis. A study indicates that the plasma level of miR-933 was elevated in patients with dementia.1 Notably, miR-933 (RS79402775) may contribute to the reduction of gastric cancer susceptibility.2 Moreover, the study found that the miR-933 expression level in superficial diffuse melanoma was lower than in nodular melanoma.3 Furthermore, miR-933 has become a reliable prognostic tool for tumor progression.4 Strikingly, single nucleotide polymorphisms of miR-933 were found to be associated with the risk of papillary thyroid cancer.5 In this study, we demonstrate that miR-933 accelerates the growth of liver cancer cells by enhancing the expression of pyruvate kinase isoform M2 (PKM2) and increasing DNA damage repair. These results provide a basis for research on liver cancer prevention.