•   Volume 2,Issue 1,2015

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    Seeking durable science through transparency and unbiased reporting
      Fei Li
      Published March 28, 2015
      2015,2(1):1 [Abstract]  [View PDF]

    Research Watch

    RhoA, a novel tumor suppressor or oncogene as a therapeutic target?
      Melissa Gilbert-Ross, Adam I. Marcus and Wei Zhou
      Published March 28, 2015
      2015,2(1):2-3 [Abstract]  [View PDF]

    Full Length Article

    Mutant KRAS as a critical determinant of the therapeutic response of colorectal cancer
      Kyle Knickelbein and Lin Zhang
      Published March 28, 2015
      2015,2(1):4-12 [Abstract]  [View PDF]
    Insulin-like growth factor (IGF) signaling in tumorigenesis and the development of cancer drug resistance
      Sahitya K. Denduluri, Olumuyiwa Idowu, Zhongliang Wang, Zhan Liao, Zhengjian Yan, Maryam K. Mohammed, Jixing Ye, Qiang Wei, Jing Wang, Lianggong Zhao and Hue H. Luu
      Published March 28, 2015
      2015,2(1):13-25 [Abstract]  [View PDF]
    Targeting Matrix Metalloproteinases in Cancer: Bringing New Life to Old Ideas
      Jillian Cathcart, Ashleigh Pulkoski-Gross and Jian Cao
      Published March 28, 2015
      2015,2(1):26-34 [Abstract]  [View PDF]
    MicroRNAs: Role in hepatitis C virus pathogenesis
      Shubham Shrivastava, Robert Steele, Ranjit Ray and Ratna B. Ray
      Published March 28, 2015
      2015,2(1):35-45 [Abstract]  [View PDF]
    The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation
      Hua Zhao, Elena Gonzalezgugel, Lei Cheng, Brendon Richbourgh, Lin Nie and Chuanju Liu
      Published March 28, 2015
      2015,2(1):46-56 [Abstract]  [View PDF]
    Signaling Pathways in Osteogenesis and Osteoclastogenesis: Lessons from Cranial Sutures and Applications to Regenerative Medicine
      Justin B. Maxhimer, James P. Bradley and Justine C. Lee
      Published March 28, 2015
      2015,2(1):57-68 [Abstract]  [View PDF]
    Epigenetic regulation of gene expression in osteoarthritis
      Mingcai Zhang and Jinxi Wang
      Published March 28, 2015
      2015,2(1):69-75 [Abstract]  [View PDF]
    Strategies to minimize hypertrophy in cartilage engineering and regeneration
      Song Chen, Peiliang Fu, Ruijun Cong, HaiShan Wu and Ming Pei
      Published March 28, 2015
      2015,2(1):76-95 [Abstract]  [View PDF]

    Short Communication

    Sustained high level transgene expression in mammalian cells mediated by the optimized piggyBac transposon system
      Xiang Chen, Jing Cui, Zhengjian Yan, Hongmei Zhang, Xian Chen, Ning Wang, Palak Shah, Fang Deng, Chen Zhao, Nisha Geng, Melissa Li, Sahitya K. Denduluri, Rex C. Haydon, Hue H. Luu, Russell R. Reid and Tong-Chuan He
      Published March 28, 2015
      2015,2(1):96-105 [Abstract]  [View PDF]