• Editorial
    • Genes & Diseases,Volume 1, Issue 2,2014, Pages 127-128
    • Wnt versus Hippo: A balanced act or dynamic duo?
    Abstract
    The Hippo signaling pathway was first discovered in Drosophila as a conserved regulator of organ size. Genetic inactivation in mice demonstrates that the Hippo pathway functions as a fundamental inhibitor of organ growth during development, and as a critical tumor suppressor in epithelial tissues.
    Keywords
    β-TrCP; Destruction complex; Hippo; Proteasome degradation; Signal transduction; Wnt/β-catenin; YAP/TAZ
    Copyright © 2014 Chongqing Medical University. Published by Elsevier B.V

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    Zhongliang Wang,Jixing Ye,Youlin Deng,Zhengjian Yan,Sahitya Denduluri,Tong-Chuan He.Wnt versus Hippo: A balanced act or dynamic duo?[J].Genes & Diseases,2014;1(2):127-128.