- Genes & Diseases,Volume 1, Issue 2,2014, Pages 127-128
- Wnt versus Hippo: A balanced act or dynamic duo?
The Hippo signaling pathway was first discovered in Drosophila as a conserved regulator of organ size. Genetic inactivation in mice demonstrates that the Hippo pathway functions as a fundamental inhibitor of organ growth during development, and as a critical tumor suppressor in epithelial tissues.
β-TrCP; Destruction complex; Hippo; Proteasome degradation; Signal transduction; Wnt/β-catenin; YAP/TAZ
Copyright © 2014 Chongqing Medical University. Published by Elsevier B.V