Specialized therapeutic delivery, or use of pharmaceuticals and other biomaterials to target specific parts of the body or diseased tissue, has long been sought as an ideal way of treating human diseases. A recent article published in Nature Biomedical Engineering revealed an innovative strategy to engineernucleus-free human mesenchymal stem cells (MSCs) for targeted delivery of therapeutics to disease site. MSCs have emerged as promising vehicles of therapeutic delivery. MSCs are undifferentiated pluripotent stem cells derived from areas such as bone marrow and adipose tissue. MSCs are sought after for their chemotaxis, or ability to home towards a chemical stimulus, and capacity for modification with elements such as chemoattractant receptors and adhesion molecules. These properties allow for site-specific and minimally-invasive therapeutic administration and treatment.
第10卷, 第2期
切换刊期年期
2023
2
RESEARCH HIGHLIGHT
研究文章2023-03-01
Zander Schwartz，Piao Zhao，Annie Wang，Guozhi Zhao，Wei Zeng，Yonghui Wang，Hue H. Luu，Rex C. Haydon，Tong-Chuan He，Russell R. Reid，Jason Strelzow
CORRIGENDA
修正2023-03-01
Xiaoxing Wu，Zhaoxia Li，Hongyu Zhang，Fang He，Min Qiao，Huaxiu Luo，Jing Zhang，Meng Zhang，Yukun Mao，William Wagstaff，Yongtao Zhang，Changchun Niu，Xia Zhao，Hao Wang，Linjuan Huang，Deyao Shi，Qing Liu，Na Ni，Kai Fu，Rex C. Haydon，Russell R. Reid，Hue H. Luu，Tong-Chuan He，Ziwei Wang，Houjie Liang，Bing-Qiang Zhang，Ning Wang
The authors regret that an image assembly (copy/paste) error in, in which the image for the organoid of "Primary MICs" group was erroneously duplicated with an image of primary MICs that was previously published. The corrected figure is shown below. As shown in the corrected Figure 3D, this error does not adversely impact the conclusion of the original work. The authors would like to apologise for any inconvenience caused.
修正2023-03-01
Chunmei Yang，Lulu Zhang，Huakun Huang，Xiaohui Yuan，Ping Zhang，Caihong Ye，Mengqi Wei，Yanran Huang，Xiaoji Luo，Jinyong Luo
The authors regret.In the MG63 panels, the 0 mm photo has been replaced.
修正2023-03-01
Chen Zhao，Wei Jiang，Nian Zhou，Junyi Liao，Mingming Yang，Ning Hu，Xi Liang，Wei Xu，Hong Chen，Wei Liu，Lewis L. Shi，Leonardo Oliveira，Jennifer Moriatis Wolf，Sherwin Ho，Aravind Athiviraham，H.M. Tsai，Tong-Chuan He，Wei Huang
The authors regret having image assembly errors in. Specifically, in, the imagesfor "C3H10T1/2", "BMP2" and "Sox9" were erroneously duplicated with the images from an irrelevant experiment that was conducted at the same time. In, the images for "Col2a1" and "β-actin" were erroneously duplicated with the images from an irrelevant experiment that was conducted at the same time.
修正2023-03-01
Zongyue Zeng，Bo Huang，Shifeng Huang，Ruyi Zhang，Shujuan Yan，Xinyi Yu，Yi Shu，Chen Zhao，Jiayan Lei，Wenwen Zhang，Chao Yang，Ke Wu，Ying Wu，Liping An，Xiaojuan Ji，Cheng Gong，Chengfu Yuan，Linghuan Zhang，Wei Liu，Yixiao Feng，Bo Zhang，Zhengyu Dai，Yi Shen，Xi Wang，Wenping Luo，Rex C. Haydon，Hue H. Luu，Lan Zhou，Russell R. Reid，Tong-Chuan He，Xingye Wu
The authors regret having an image assembly error in, in which the image for the "0h dBiFP-AdRFP" group was erroneously duplicated with an overlapping image from the "36h BiFP dBIFP-AdR-simH19" group.
修正2023-03-01
Xinyi Yu，Liqun Chen，Ke Wu，Shujuan Yan，Ruyi Zhang，Chen Zhao，Zongyue Zeng，Yi Shu，Shifeng Huang，Jiayan Lei，Xiaojuan Ji，Chengfu Yuan，Linghuan Zhang，Yixiao Feng，Wei Liu，Bo Huang，Bo Zhang，Wenping Luo，Xi Wang，Bo Liu，Rex C. Haydon，Hue H. Luu，Tong-Chuan He，Hua Gan
The authors regret having an image assembly error in, in whichthe image for "imPODSynaptopodin DAPI stain" group was erroneously duplicated with the image from the "tsPOD-33℃ Synaptopodin DAPI stain" group.
修正2023-03-01
Shujuan Yan，Ruyi Zhang，Ke Wu，Jing Cui，Shifeng Huang，Xiaojuan Ji，Liping An，Chengfu Yuan，Cheng Gong，Linghuan Zhang，Wei Liu，Yixiao Feng，Bo Zhang，Zhengyu Dai，Yi Shen，Xi Wang，Wenping Luo，Bo Liu，Rex C. Haydon，Michael J. Lee，Russell R. Reid，Jennifer Moriatis Wolf，Qiong Shi，Hue H. Luu，Tong-Chuan He，Yaguang Weng
The authors regret having several image assembly errors. Specifically, in panel b, the image for "AdsimB9-4 only" group was erroneously duplicated with an overlapping image from the "AdRFP" group; and the image for "AdsimB9-1+BMP9" group was erroneously duplicated with an overlapping image from "AdsimB9-8+BMP9" group. In panel a, the images for "BMP9" group and "BMP9+simB9-4" group were erroneously duplicated with an overlapping image from "simB9-4" group. In, the image for "BMP9+simB9-4/Day3" group was erroneously duplicated with an overlapping image from "BMP9+simB9-7/Day3" group; and the image for "BMP9+simB9-4/Day5" group was erroneously duplicated with an overlapping image from an unrelated experiment. In, the image for "BMP9+simB9-7/Day 11" group was erroneously duplicated with an overlapping image from the "BMP9+simB9-4/Day 11" group.
